IM1xIPC81.RdThis is the raw data documenting the influence of the alkyl chain length in 3 position on the toxicity to the promyelocytic leukemia rat cell line IPC-81. The substances are named according to the UFT naming scheme of these substances. IM13 BF4 means 1-methyl-3-propylimidazolium tetrafluoroborate, IM14 BF4 means 1-methyl-3-butylimidazolium tetrafluoroborate and IM1-10 BF4 means 1-methyl-3-decylimidazolium tetrafluoroborate. This is a subset (only the BF4 anion) of the data shown in Figure 3 in Ranke et al. (2004).
data(IM1xIPC81)A dataframe containing the data as required for the
drfit function. An additional column contains
the tested organism (name of the cell line).
Ranke J, Mölter K, Stock F, Bottin-Weber U, Poczobutt J, Hoffmann J, Ondruschka B, Filser J, Jastorff B (2004) Biological effects of imidazolium ionic liquids with varying chain lenghts in acute Vibrio fischeri and WST-1 cell viability assays. Ecotoxicology and Environmental Safety 58(3) 396-404
rIM1xIPC81 <- drfit(IM1xIPC81, linlogit = TRUE, showED50 = TRUE, EDx = 10)
#>
#> IM13 BF4: Fitting data...
#>
#> IM14 BF4: Fitting data...
#> Warning: NaNs produced
#>
#> IM15 BF4: Fitting data...
#>
#> IM16 BF4: Fitting data...
#>
#> IM17 BF4: Fitting data...
#> Waiting for profiling to be done...
#> Warning: NaNs produced
#>
#> IM18 BF4: Fitting data...
#> Waiting for profiling to be done...
#> Warning: NaNs produced
#>
#> IM19 BF4: Fitting data...
#> Waiting for profiling to be done...
#> Warning: NaNs produced
#>
#> IM1-10 BF4: Fitting data...
#> Waiting for profiling to be done...
rIM1xIPC81.drc <- drcfit(IM1xIPC81, linlogit = TRUE, showED50 = TRUE, EDx = 10)
#>
#> IM13 BF4: Fitting data...
#>
#> IM14 BF4: Fitting data...
#>
#> IM15 BF4: Fitting data...
#>
#> IM16 BF4: Fitting data...
#>
#> IM17 BF4: Fitting data...
#>
#> IM18 BF4: Fitting data...
#>
#> IM19 BF4: Fitting data...
#>
#> IM1-10 BF4: Fitting data...
print(rIM1xIPC81,digits=4)
#> Substance ndl n lld lhd mtype logED50 2.5% 97.5% unit sigma
#> 1 IM13 BF4 9 81 0.5918 3.000 inactive NA NA NA microM NA
#> 2 IM14 BF4 20 216 -0.0103 3.176 no fit NA NA NA microM NA
#> 3 IM15 BF4 9 135 0.5918 3.000 inactive NA NA NA microM NA
#> 4 IM16 BF4 9 108 0.5918 3.000 inactive NA NA NA microM NA
#> 5 IM17 BF4 9 81 0.5918 3.000 linlogit 2.5786 2.506 2.6617 microM 0.2376
#> 6 IM18 BF4 9 135 0.5918 3.000 linlogit 1.6806 1.623 1.7419 microM 0.2325
#> 7 IM19 BF4 9 81 0.5918 3.000 linlogit 1.6496 1.598 1.7031 microM 0.1453
#> 8 IM1-10 BF4 11 162 -0.0103 3.000 linlogit 0.7697 0.687 0.8544 microM 0.2988
#> a b c ED50 ED50 2.5% ED50 97.5% EDx10
#> 1 NA NA NA NA NA NA NA
#> 2 NA NA NA NA NA NA NA
#> 3 NA NA NA NA NA NA NA
#> 4 NA NA NA NA NA NA NA
#> 5 2.5786 2.300 0.01468 378.941 320.424 458.918 230.782
#> 6 1.6806 2.237 0.05719 47.930 41.973 55.194 27.367
#> 7 1.6496 1.977 0.10956 44.628 39.671 50.483 23.031
#> 8 0.7697 1.936 0.45809 5.884 4.864 7.152 2.835
print(rIM1xIPC81.drc,digits=4)
#> Substance ndl n lld lhd mtype logED50 2.5% 97.5% unit sigma
#> 1 IM13 BF4 9 81 0.5918 3.000 inactive NA NA NA microM NA
#> 2 IM14 BF4 20 216 -0.0103 3.176 linlogit NA NA NA microM 0.1529
#> 3 IM15 BF4 9 135 0.5918 3.000 inactive NA NA NA microM NA
#> 4 IM16 BF4 9 108 0.5918 3.000 inactive NA NA NA microM NA
#> 5 IM17 BF4 9 81 0.5918 3.000 linlogit 2.5786 2.4935 2.6497 microM 0.2376
#> 6 IM18 BF4 9 135 0.5918 3.000 linlogit 1.6806 1.6168 1.7362 microM 0.2325
#> 7 IM19 BF4 9 81 0.5918 3.000 linlogit 1.6496 1.5940 1.6990 microM 0.1453
#> 8 IM1-10 BF4 11 162 -0.0103 3.000 linlogit 0.7697 0.6774 0.8458 microM 0.2988
#> a b c ED50 ED50 2.5% ED50 97.5% EDx10 EDx10 2.5%
#> 1 NA NA NA NA NA NA NA NA
#> 2 5.390e+15 0.3148 -0.0001736 NA NA NA NA NA
#> 3 NA NA NA NA NA NA NA NA
#> 4 NA NA NA NA NA NA NA NA
#> 5 1.281e+02 2.3001 0.0146821 378.964 311.555 446.372 230.790 202.915
#> 6 2.079e+01 2.2373 0.0571925 47.930 41.382 54.478 27.367 23.809
#> 7 1.342e+01 1.9773 0.1094542 44.630 39.260 50.000 23.036 20.614
#> 8 2.258e+00 1.9362 0.4580784 5.884 4.758 7.011 2.835 2.181
#> EDx10 97.5%
#> 1 NA
#> 2 NA
#> 3 NA
#> 4 NA
#> 5 258.665
#> 6 30.925
#> 7 25.459
#> 8 3.489